Yu Shi, Assistant Professor
Research Areas
Biophysics, active matter physics, cell mechanics, super resolution microscopy, single molecule imaging
Research Interests
Our lab seeks to understand how macroscopic cell behaviors arise from the microscopic interactions of polymer building blocks. To address this question, we aim to investigate cellular structure, dynamics, and mechanics across multiple length scales simultaneously. We leverage cutting-edge tools in biomechanics and advanced optical microscopy, and we are also interested in applying machine learning to enhance our research.
Publications
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Daugird, T.A.*, Shi, Y.*, Holland, K.L., Rostamian, H., Liu, Z., Lavis, L.D., Rodriguez, J., Strahl, B.D., and Legant, W.R. Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment. Nat Commun 15, 4178 (2024). https://doi.org/10.1038/s41467-024-48562-0 *These authors contributed equally to this work
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Shi, Y*., Tabet, J.S.*, Milkie, D.E., Daugird, T.A., Yang, Q.C., Ritter, A.T., Giovannucci, A. and Legant, W.R. Smart lattice light-sheet microscopy for imaging rare and complex cellular events. Nat Methods 21, 301–310 (2024). https://doi.org/10.1038/s41592-023-02126-0 (Cover work of the issue) *These authors contributed equally to this work
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Shi, Y., Daugird, T.A. and Legant, W.R. A quantitative analysis of various patterns applied in lattice light sheet microscopy. Nat Commun 13, 4607 (2022). https://doi.org/10.1038/s41467-022-32341-w
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Shi, Y., Porter, C.L., Crocker, J.C., and Reich, D.H. Dissecting fat-tailed fluctuations in the cytoskeleton with active micropost arrays. PNAS 116 (28), 13839-13846 (2019)
Teaching
Undergraduate:
Physics 2110A: Oscillations and Waves
Awards
- UNC-Chapel Hill BME Achievement Award, 2023
