Alexei Ouriadov, Assistant Professor

Research Interests: Hyperpolarized (HP) 129Xe MRI was proven to be useful for visualization of ventilated lung regions, obtaining regional information about the lung alveolar geometries, observing oxygen-like gas exchange between xenon “dissolved” in the lung tissue and red blood cells and also imaging of the brain blood supply on the dissolved xenon frequency (i.e.,multi-phase xenon). However, even after 20 years of developing HP 129Xe MRI, fundamental limitations specific to this imaging modality have remained unresolvable, until now. A good example of such limitations is the low signal-to-noise ratio of 129Xe images. My current research interests include the development of new image acquisition, reconstruction and processing methods, advanced MRI hardware (RF coils) and a static cell xenon polarizer in order to resolve the remaining shortcomings of HP multi-phase, perfusion and biosensor 129Xe MRI and furthermore to validate this imaging method vs. the well-established PET imaging modality.

1. Samuel P, McCormack, DG, Parraga G, and Ouriadov A. Undersampled Diffusion-weighted 129Xe MRI Morphometry of Airspace Enlargement: Feasibility in Chronic Obstructive Pulmonary Disease. Diagnostics (Basel) 2023
2. Perron, S., Ouriadov, A. “Hyperpolarized 129Xe MRI at low field: Current status and future directions” (2023) Journal of Magnetic Resonance, 348, art. no. 107387. DOI:10.1016/j.jmr.2023.107387
3. Sembhi, R., Ranota, T., Fox, M., Couch, M., Li, T., Ball, I., Ouriadov, A. “Feasibility of Dynamic Inhaled Gas MRI-Based Measurements Using Acceleration Combined with the Stretched Exponential Model” (2023) Diagnostics, 13 (3), art. no. 506. DOI:10.3390/diagnostics13030506
4. Perron, S., Ouriadov, A., Wawrzyn, K., Hickling, S., Fox, M.S., Serrai, H., Santyr, G. “Application of a 2D frequency encoding sectoral approach to hyperpolarized 129Xe MRI at low field” (2022) Journal of Magnetic Resonance, 336, art. no. 107159 DOI:10.1016/j.jmr.2022.107159
5. Ouriadov, A.V., Fox, M.S., Lindenmaier, A.A., Stirrat, E., Serrai, H., Santyr, G. “Application of a stretched-exponential model for morphometric analysis of accelerated diffusion-weighted 129Xe MRI of the rat lung” (2021) Magnetic Resonance Materials in Physics, Biology and Medicine, 34 (1), pp. 73-84. DOI:10.1007/s10334-020-00860-6

[Complete Publication Listing (Scopus)]

Undergraduate:
Physics 1202: Physics for the Sciences II
Physics 3400: Introduction to Thermal Physics
Physics 4662: Nuclear Magnetic Resonance

Graduate:
Physics 9404: Statistical Physics
Physics 9610: Fundamentals of Physics
Physics 9660: Nuclear Magnetic Resonance

• Scientist, Lawson Health Research Institute