My research focus is the development of ultrasonic techniques for non-invasive imaging and flow visualization, primarily to elucidate the connections between vascular tissue changes and local hemodynamics. The development and progression of vascular disease involves an inherent feedback loop whereby local hemodynamics (e.g. oscillating shear) affect tissue changes (e.g. plaque development), which in turn affect the hemodynamics (e.g. turbulence). Hence, to investigate the role of hemodynamics in vascular disease, it is important to be able to map out and characterize the local hemodynamics relative to the tissue geometry and composition (available through various imaging modalities, incl. ultrasound), as well as follow any correlated tissue and hemodynamic changes.
Kefayati S, Holdsworth DW, Poepping TL. (2013) "Turbulence Intensity Measurements Using Particle Image Velocimetry in Diseased Carotid Artery Models: Effect of Stenosis Severity, Plaque Eccentricity, and Ulceration." J. Biomechanics (accepted Sept. 2013)
Wong EY, Nikolov HN, Rankin RN, Holdsworth DW, Poepping TL. (2013) "Evaluation of distal turbulence intensity for the detection of both plaque ulceration and stenosis grade in the carotid bifurcation using clinical Doppler ultrasound." Eur. Radiol. 23(6):1720-1728.
Kefayati S and Poepping TL. (2013) “Transitional Flow Analysis in the Carotid Artery Bifurcation by Proper Orthogonal Decomposition and Particle Image Velocimetry.” Med. Eng. Phys. 35(7):898-909.